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Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

《医学前沿（英文）》 2011年第5卷第4期页码 323-332 doi: 10.1007/s11684-011-0172-4

摘要：

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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

《医学前沿（英文）》 doi: 10.1007/s11684-023-1044-4

摘要： As of May 3, 2023, the coronavirus disease 2019 (COVID-19) pandemic has resulted in more than 760 million confirmed cases and over 6.9 million deaths. Several patients have developed pneumonia, which can deteriorate into acute respiratory distress syndrome. The primary etiology may be attributed to cytokine storm, which is triggered by the excessive release of proinflammatory cytokines and subsequently leads to immune dysregulation. Considering that high levels of interleukin-6 (IL-6) have been detected in several highly pathogenic coronavirus-infected diseases, such as severe acute respiratory syndrome in 2002, the Middle East respiratory syndrome in 2012, and COVID-19, the IL-6 pathway has emerged as a key in the pathogenesis of this hyperinflammatory state. Thus, we review the history of cytokine storm and the process of targeting IL-6 signaling to elucidate the pivotal role played by tocilizumab in combating COVID-19.

关键词： SARS-CoV-2 COVID-19 cytokine storm interleukin-6 tocilizumab

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Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst

Seiichi Taguchi

《化学科学与工程前沿（英文）》 2017年第11卷第1期页码 139-142 doi: 10.1007/s11705-017-1636-0

摘要： Establishment of the regeneratable whole-cell catalyst platform for the?production of biobased polymeric materials is a?typical topic of synthetic biology. In this commentary, discovery story of a “lactate-polymerizing enzyme” (LPE)?and LPE-based?achievements for creating a new variety of polyesters with incorporated unnatural monomers are presented. Besides the importance of microbial platform itself is discussed referring to the “ballooning”- .

关键词： synthetic biology enzyme evolutionary engineering polyhydroxyalkanoate

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MicroRNAs and lung cancers: from pathogenesis to clinical implications

null

《医学前沿（英文）》 2012年第6卷第2期页码 134-155 doi: 10.1007/s11684-012-0188-4

摘要：

Lung cancer is the leading cause of cancer-related deaths in the US and worldwide. Better understanding of the disease is warranted for improvement in clinical management. Here we summarize the functions of small-RNA-based, posttranscriptional gene regulators, i.e. microRNAs, in the pathogenesis of lung cancers. We discuss the microRNAs that play oncogenic as well as tumor suppressive roles. We also touch on the value of microRNAs as markers for diagnosis, prognosis and the promising field of microRNA-based novel therapies for lung cancers.

关键词： lung biology lung cancer microRNA

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Approximation of structural damping and input excitation force

Mohammad SALAVATI

《结构与土木工程前沿（英文）》 2017年第11卷第2期页码 244-254 doi: 10.1007/s11709-016-0371-9

摘要： Structural dynamic characteristics are the most significant parameters that play a decisive role in structural damage assessment. The more sensitive parameter to the damage is the damping behavior of the structure. The complexity of structural damping mechanisms has made this parameter to be one of the ongoing research topics. Despite all the difficulties in the modeling of damping, there are some approaches like as linear and nonlinear models which are described as the energy dissipation throughout viscous, material or structural hysteretic and frictional damping mechanisms. In the presence of a mathematical model of the damping mechanisms, it is possible to estimate the damping ratio from the theoretical comparison of the damped and un-damped systems. On the other hand, solving the inverse problem of the input force estimation and its distribution to each SDOFs, from the measured structural responses plays an important role in structural identification process. In this paper model-based damping approximation method and a model-less structural input estimation are considered. The effectiveness of proposed methods has been carried out through analytical and numerical simulation of the lumped mass system and the results are compared with reference data. Consequently, high convergence of the comparison results illustrates the satisfactory of proposed approximation methods.

关键词： structural modal parameters damping identification method input excitation force identification Inverse problem

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Effects of green roof damping and configuration on structural seismic response

《结构与土木工程前沿（英文）》页码 1133-1144 doi: 10.1007/s11709-023-0959-9

摘要： Sustainable structures are critical for addressing global climate change. Hence, their structural resilience or ability to recover from natural events must be considered comprehensively. Green roofs are a widely used sustainable feature that improve the environment while providing excellent occupant amenity. To expand their usage, their inherent damping and layout sensitivity to seismic performance are investigated in this study. The soil of a green roof can serve as a damper to dissipate the energy generated by earthquakes or other dynamic events. Results of preliminary analysis show that a green roof soil can increase localized damping by 2.5% under both dry and saturated conditions. Based on these findings, nonlinear time-history analyses are conducted on a three-story building in SAP2000 to monitor the structural behavior with and without a green roof. The increased damping in the green roof soil is beneficial to the structural performance, i.e., it reduces the building displacement and acceleration by 10% and 12%, respectively. Additionally, certain configurations are more effective and beneficial to the structural response than others, which suggests the possibility of design optimization. Based on the findings of this study, new methods of modeling and considering green roofs in structural design are established.

关键词： green infrastructure green roof structural resilience seismic design

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Development of an integrated structural health monitoring system for bridge structures in operational

Xinqun ZHU, Hong HAO

《结构与土木工程前沿（英文）》 2012年第6卷第3期页码 321-333 doi: 10.1007/s11709-012-0161-y

摘要： This paper presents an overview of development of an integrated structural health monitoring system. The integrated system includes vibration and guided-wave based structural health monitoring. It integrates the real-time heterogeneous sensor data acquiring system, data analysis and interpretation, physical-based numerical simulation of complex structural system under operational conditions and structural evaluation. The study is mainly focused on developing: integrated sensor technology, integrated structural damage identification with operational loads monitoring, and integrated structural evaluation with results from system identification. Numerical simulation and its implementation in laboratory show that the system is effective and reliable to detect local damage and global conditions of bridge structures.

关键词： integrated structural health monitoring operational conditions vibration and guided wave

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Digital image correlation-based structural state detection through deep learning

《结构与土木工程前沿（英文）》 2022年第16卷第1期页码 45-56 doi: 10.1007/s11709-021-0777-x

摘要： This paper presents a new approach for automatical classification of structural state through deep learning. In this work, a Convolutional Neural Network (CNN) was designed to fuse both the feature extraction and classification blocks into an intelligent and compact learning system and detect the structural state of a steel frame; the input was a series of vibration signals, and the output was a structural state. The digital image correlation (DIC) technology was utilized to collect vibration information of an actual steel frame, and subsequently, the raw signals, without further pre-processing, were directly utilized as the CNN samples. The results show that CNN can achieve 99% classification accuracy for the research model. Besides, compared with the backpropagation neural network (BPNN), the CNN had an accuracy similar to that of the BPNN, but it only consumes 19% of the training time. The outputs of the convolution and pooling layers were visually displayed and discussed as well. It is demonstrated that: 1) the CNN can extract the structural state information from the vibration signals and classify them; 2) the detection and computational performance of the CNN for the incomplete data are better than that of the BPNN; 3) the CNN has better anti-noise ability.

关键词： structural state detection deep learning digital image correlation vibration signal steel frame

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Identification of structural parameters and boundary conditions using a minimum number of measurement

Ali KARIMPOUR, Salam RAHMATALLA

《结构与土木工程前沿（英文）》 2020年第14卷第6期页码 1331-1348 doi: 10.1007/s11709-020-0686-4

摘要： This article proposes a novel methodology that uses mathematical and numerical models of a structure to build a data set and determine crucial nodes that possess the highest sensitivity. Regression surfaces between the structural parameters and structural output features, represented by the natural frequencies of the structure and local transmissibility, are built using the numerical data set. A description of a possible experimental application is provided, where sensors are mounted at crucial nodes, and the natural frequencies and local transmissibility at each natural frequency are determined from the power spectral density and the power spectral density ratios of the sensor responses, respectively. An inverse iterative process is then applied to identify the structural parameters by matching the experimental features with the available parameters in the myriad numerical data set. Three examples are presented to demonstrate the feasibility and efficacy of the proposed methodology. The results reveal that the method was able to accurately identify the boundary coefficients and physical parameters of the Euler-Bernoulli beam as well as a highway bridge model with elastic foundations using only two measurement points. It is expected that the proposed method will have practical applications in the identification and analysis of restored structural systems with unknown parameters and boundary coefficients.

关键词： structural model validation eigenvalue problem response surface inverse problems

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Advanced analysis for structural steel building design

CHEN Wai Fah

《结构与土木工程前沿（英文）》 2008年第2卷第3期页码 189-196 doi: 10.1007/s11709-008-0024-8

摘要： The 2005 AISC LRFD Specifications for Structural Steel Buildings are making it possible for designers to recognize explicitly the structural resistance provided within the elastic and inelastic ranges of behavior and up to the maximum load limit state. There is an increasing awareness of the need for practical second-order analysis approaches for a direct determination of overall structural system response. This paper attempts to present a simple, concise and reasonably comprehensive introduction to some of the theoretical and practical approaches which have been used in the traditional and modern processes of design of steel building structures.

关键词： building Specifications comprehensive introduction structural resistance traditional

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Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

《化学科学与工程前沿（英文）》 2017年第11卷第1期页码 37-45 doi: 10.1007/s11705-017-1618-2

摘要： The ability to go from a digitized DNA sequence to a predictable biological function is central to synthetic biology. Genome engineering tools facilitate rewriting and implementation of engineered DNA sequences. Recent development of new programmable tools to reengineer genomes has spurred myriad advances in synthetic biology. Tools such as clustered regularly interspace short palindromic repeats enable RNA-guided rational redesign of organisms and implementation of synthetic gene systems. New directed evolution methods generate organisms with radically restructured genomes. These restructured organisms have useful new phenotypes for biotechnology, such as bacteriophage resistance and increased genetic stability. Advanced DNA synthesis and assembly methods have also enabled the construction of fully synthetic organisms, such as J. Craig Venter Institute (JCVI)-syn 3.0. Here we summarize the recent advances in programmable genome engineering tools.

关键词： CRISPR genome engineering synthetic biology rational design

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Estimation of optimum design of structural systems via machine learning

《结构与土木工程前沿（英文）》 2021年第15卷第6期页码 1441-1452 doi: 10.1007/s11709-021-0774-0

摘要： Three different structural engineering designs were investigated to determine optimum design variables, and then to estimate design parameters and the main objective function of designs directly, speedily, and effectively. Two different optimization operations were carried out: One used the harmony search (HS) algorithm, combining different ranges of both HS parameters and iteration with population numbers. The other used an estimation application that was done via artificial neural networks (ANN) to find out the estimated values of parameters. To explore the estimation success of ANN models, different test cases were proposed for the three structural designs. Outcomes of the study suggest that ANN estimation for structures is an effective, successful, and speedy tool to forecast and determine the real optimum results for any design model.

关键词： optimization metaheuristic algorithms harmony search structural designs machine learning artificial neural networks

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Proposal of a probabilistic assessment of structural collapse concomitantly subject to earthquake and

Gholamreza ABDOLLAHZADEH, Hadi FAGHIHMALEKI

《结构与土木工程前沿（英文）》 2018年第12卷第3期页码 425-437 doi: 10.1007/s11709-017-0427-5

摘要：

In recent decades, many public buildings, located in seismic-prone residential areas, had to grapple with abnormal loads against which the structures were unguarded. In this piece of research, an ordinary three dimensional reinforced concrete building is selected as case study. The building is located in an earthquake-prone region; however, it is designed according to seismic building codes. Yet, it is not shielded against abnormal loads, such as blasts. It is assumed that the building suffers a blast load, due to mechanical/thermal installation failure during or after intense seismic oscillations. These two critical incidents are regarded codependent and compatible. So the researchers developed scenarios and tried to assess different probabilities for each scenario and carried out an analysis to ensure if progressive collapse had set in or not. In the first step, two analysis models were used for each scenario; a non-linear dynamic time history analysis and a blast local dynamic analysis. In the second step, having the structural destructions of the first step in view, a pushdown analysis was carried out to determine the severity of progressive collapse and assess building robustness. Finally, the annual probability of structural collapse under simultaneous earthquake and blast loads was estimated and offered.

关键词： gas blast pushdown analysis progressive collapse annual probability of structural collapse 3D model of structure

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Stress-strain relationship with soil structural parameters of collapse loess

SHAO Shengjun, LONG Jiyong, YU Qinggao

《结构与土木工程前沿（英文）》 2008年第2卷第2期页码 151-160 doi: 10.1007/s11709-008-0020-z

摘要： Through the tri-axial shearing tests of unsaturated intact loess and based on the concept of comprehensive soil structural potential, this paper reveals the changing laws of soil structural property under the tri-axial stress conditions and establishes a mathematical expression equation of structural parameters, whereby reflecting the effects of unsaturated loess water content, stress and strain states, which is introduced into the shearing stress and shearing strain relation to obtain the structural stress-strain relation. The tests reveal that the loess dilatancy is of shearing contraction and shearing expansion, whereby indicating that there is a good linear relation between the stress ratio and shearing expansion strain ratio. The larger consolidation confining pressure is, the larger the stress of shearing contraction and expansion critical point is; and the larger water content is, the smaller the strain ratio of shearing contraction and expansion critical point is. Finally, the constitutive model is established to reflect the variation in loess structure, stress-strain softening and hardening, and shearing contraction and shearing expansion features. Through the comparative analysis, the stress-strain curves described by the constitutive relationship are found to be in good conformity with test results, whereby testing the rationality of the model in this paper.

关键词： hardening shearing expansion unsaturated structural property mathematical expression

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XFEM schemes for level set based structural optimization

Li LI, Michael Yu WANG, Peng WEI

《机械工程前沿（英文）》 2012年第7卷第4期页码 335-356 doi: 10.1007/s11465-012-0351-2

摘要：

In this paper, some elegant extended finite element method (XFEM) schemes for level set method structural optimization are proposed. Firstly, two- dimension (2D) and three-dimension (3D) XFEM schemes with partition integral method are developed and numerical examples are employed to evaluate their accuracy, which indicate that an accurate analysis result can be obtained on the structural boundary. Furthermore, the methods for improving the computational accuracy and efficiency of XFEM are studied, which include the XFEM integral scheme without quadrature sub-cells and higher order element XFEM scheme. Numerical examples show that the XFEM scheme without quadrature sub-cells can yield similar accuracy of structural analysis while prominently reducing the time cost and that higher order XFEM elements can improve the computational accuracy of structural analysis in the boundary elements, but the time cost is increasing. Therefore, the balance of time cost between FE system scale and the order of element needs to be discussed. Finally, the reliability and advantages of the proposed XFEM schemes are illustrated with several 2D and 3D mean compliance minimization examples that are widely used in the recent literature of structural topology optimization. All numerical results demonstrate that the proposed XFEM is a promising structural analysis approach for structural optimization with the level set method.

关键词： structural optimization level set method extended finite element method (XFEM) computational accuracy and efficiency